French healthcare company Sanofi said it would stop further work on amcenestrant, once seen to have large potential
against breast cancer, after a second trial failure dealt a major blow to its drug development prospects.
The move puts more pressure on Sanofi to bolster its drug development pipeline as it grows increasingly dependent on its multi-billion best seller, exzecma and asthma treatment Dupixent, and after it fell far behind in the race to develop COVID-19 vaccines.
A trial dubbed AMEERA-5, which was testing amcenestrant on women with newly-diagnosed advanced breast cancer, was stopped early because an independent monitoring panel found no signs of it working.
"All other studies of amcenestrant, including in early-stage breast cancer (AMEERA-6), will be discontinued," Sanofi said. The shares dropped 1.5% shortly after the market open at 0700 GMT, for the biggest loss on the French blue chip index CAC40 In March, Sanofi's shares were hit when the company announced disappointing results of a breast cancer study involving previously treated women.
The company has previously said the drug candidate's biggest commercial opportunity was as a treatment early after diagnosis. "This was a flagship drug in pipeline and important oncology asset," wrote Credit Suisse analyst Jo Walton.
Sanofi said the drug, which was used in combination with Pfizer's established Ibrance in the study, "did not meet the prespecified boundary for continuation," when compared to a group of patients in the trial on standard hormone therapy.
Amcenestrant belongs to a drug class known as selective oestrogen receptor degraders (SERD) to fight tumours that grow in response to oestrogen, which are estimated to account for up to 80% of all breastcancer cases.
The market opportunity for oral SERDs has attracted a range of drugmakers. Sanofi's rivals including Roche and AstraZeneca are working on similar pills, known as giredestrant and camizestrant, respectively.
The drugs are designed to work like AstraZeneca's established injectable breast cancer drug Faslodex, while offering a less burdensome route of administration.
Separately, the plaintiff in the first lawsuit over the heartburn drug Zantac, which has also been weighing on the French company's shares recently, on Tuesday agreed to drop his case.
Sanofi was among a range of companies selling Zantac, which U.S. regulators pulled from the market in 2020.
(This story has not been edited by VOH and is auto-generated from a syndicated feed.)
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By: PTI-06/10/2022
Apollo Hospitals acquires 60 pc stake in
By: PTI-06/10/2022
PM Modi inaugurates AIIMS Bilaspur
By: PTI-06/10/2022
BA.2 variant in around 90 pc Covid sampl
By: PTI-06/10/2022
Coronavirus formation modelled for first
By: PTI-06/10/2022
LIC increases its stake in Dr Reddy's La
By: PTI-04/10/2022
Singapore plans to hire 180 junior docto
By: PTI-04/10/2022
How COVID damages heart found, may lead
By: PTI-04/10/2022
Increasing number of private wards at AI
By: PTI-04/10/2022
Viral infections including COVID are amo
By: PTI-04/10/2022
From civil hospital to public health lab
By: PTI-03/10/2022
Doctors participate in walkathon to prot
By: PTI-03/10/2022
QR codes posted in Bengaluru traffic jun
By: PTI-03/10/2022
Govt to soon launch national tele-mental
By: PTI-03/10/2022
Overlapping symptoms of dengue, Covid-19
By: PTI-03/10/2022
Healthy Heart Challenge: Ensuring cardia
By: PTI-01/10/2022
New drug may turn Covid virus against it
By: PTI-01/10/2022
Delhi records three more monkeypox cases
By: PTI-01/10/2022
Lupin launches generic hypertension drug
By: PTI-30/09/2022
DCGI allows Serum Institute to export ma
By: PTI-30/09/2022
Air pollution may increase COVID severit
By: PTI-30/09/2022
Unite efforts to reduce premature mortal
By: PTI-30/09/2022
HC quashes NPPA demand notices to Bharat
By: PTI-30/09/2022
Tobacco major risk factor for heart dise
By: PTI-29/09/2022
COVID shots linked with temporary increa
By: PTI-29/09/2022
Delhi CM launches blood donation drive,
By: PTI-29/09/2022
Aesthetic surgeries to be done by regist
By: PTI-28/09/2022
Natl Clean Air Programme: Centre aims at
By: PTI-28/09/2022
SII's Adar Poonawalla makes clarion call
By: PTI-28/09/2022
Dengue cases on rise in West Bengal, 840
By: PTI-28/09/2022
New Covid-like virus found in bats could
By: PTI-27/09/2022
India's healthcare system has shown grea
By: PTI-27/09/2022
J-K has registered remarkable improvemen
By: PTI-27/09/2022
Covid helpline received 6.62 lakh calls
By: PTI-26/09/2022
PLI schemes should also focus on entitie
By: PTI-26/09/2022
New AIIMS director M Srinivas issues ord
By: PTI-26/09/2022
COVID pandemic created immunisation gaps
By: PTI-26/09/2022
New cutting-edge tech diagnoses heart fa
By: PTI-26/09/2022
COVID-19 infection increases risk of lon
By: PTI-24/09/2022
Nearly 90 pc Covid samples genome-sequen
By: PTI-24/09/2022
HC directs Delhi govt to ensure advanced
By: PTI-24/09/2022
Only 19% aged above-18 have taken 3rd CO
By: PTI-24/09/2022
Scientists engineer mosquitoes that can'
By: PTI-24/09/2022
Odisha seeks Bihar's help to check fake
By: PTI-23/09/2022
Robotic kidney transplant done at Safdar
By: PTI-23/09/2022
ICMR, IISc ink pact to create high-quali
By: PTI-23/09/2022
Assam to use portable device 'SAANS' to
By: PTI-23/09/2022
New cases of severe long COVID appear to
By: PTI-22/09/2022
Air pollution may increase hospitalisati
By: PTI-22/09/2022
Government forms committee to regulate m
By: PTI-22/09/2022
Covid-19 infection increases risk of blo
By: PTI-22/09/2022
BridgeBio Pharma, Sentynl Therapeutics g
By: PTI-22/09/2022
Discontinuation of small pox vaccine mig
By: PTI-21/09/2022
'Night owls' may have higher risk of dia
By: PTI-21/09/2022
Mizoram Governor urges people to spread
By: PTI-21/09/2022
Bihar cabinet nod for around 8,000 more
By: PTI-21/09/2022
Alzheimer's might not be primarily a bra
By: PTI-21/09/2022
11 upcoming hospitals to boost health in
By: PTI-20/09/2022
IIIT-Delhi researchers develop AI-based
By: PTI-20/09/2022
Novel test can identify patients at risk
By: PTI-20/09/2022
Indoco Remedies' CRO clears USFDA inspec
By: PTI-20/09/2022
Gujarat govt extends OPD timings in stat
By: PTI-19/09/2022
Post-ICU rehabilitation project launched
By: PTI-19/09/2022
Tata Memorial Centre inks MoU with Balco
By: PTI-19/09/2022
Indian scientist and industrialist Swati
By: PTI-19/09/2022
Portal launched recently provides info o
By: PTI-19/09/2022
Not just big pharma: how social factors
By: PTI-17/09/2022
Govt launches diabetes drug Sitagliptin,
By: PTI-17/09/2022
Active Covid-19 cases in country rise to
By: PTI-17/09/2022
WHO strongly advises against use of two
By: PTI-17/09/2022
Lancet report highlights 'massive global
By: PTI-16/09/2022
Israelis to be administered variant tail
By: PTI-16/09/2022
Malaria vaccine: the road has been long
By: PTI-16/09/2022
Single dose of alcohol may be enough to
By: PTI-16/09/2022
Another new COVID variant is spreading -
By: PTI-15/09/2022
Lancet report on unapproved antibiotic u
By: PTI-15/09/2022
Novel plastic film can kill Covid virus
By: PTI-15/09/2022
Lumpy Skin Disease: Safe to consume milk
By: PTI-15/09/2022
Make organ donation mandatory after deat
By: PTI-14/09/2022
Easy to use, more effective and cheap, n
By: PTI-14/09/2022
Twice-daily nasal saline flushing may re
By: PTI-14/09/2022
Kerala govt initiates steps to identify
By: PTI-14/09/2022
If there was SDG on COVID-19 management,
By: PTI-14/09/2022
New intranasal anti-viral treatment may
By: PTI-13/09/2022
Centre along with states trying to contr
By: PTI-13/09/2022
Paras Healthcare ties up with Fujifilm f
By: PTI-13/09/2022
Survey reveals low awareness about cance
By: PTI-12/09/2022
Lumpy skin disease: Delhi govt to procur
By: PTI-12/09/2022
WHO releases global guidelines to boost
By: PTI-12/09/2022
Drug regulator's nod sought for phase-3
By: PTI-12/09/2022
Monkeypox may cause neurological damage,
By: PTI-12/09/2022
Monkeypox vaccine expected to induce str
By: PTI-10/09/2022
WHO Regional Committee meet concludes, m
By: PTI-10/09/2022
Lupin receives US FDA approval for gener
By: PTI-10/09/2022
Zydus acquires rights to market MonoFerr
By: PTI-10/09/2022
PM Modi lauds physiotherapists, says the
By: PTI-09/09/2022
USFDA asks Panacea Biotec to take correc
By: PTI-09/09/2022
CIPACA ties up with ImpactGuru.com to of
By: PTI-09/09/2022
Two antibodies identified in Israel may
By: PTI-09/09/2022
Odisha signs MOU with Tata Memorial Cent
By: PTI-09/09/2022
US Prez Joe Biden announces launch of an
By: PTI-08/09/2022
Over 47 per cent antibiotic formulations
By: PTI-08/09/2022
Cipla gets USFDA nod for cancer drug
By: PTI-08/09/2022
WHO Southeast Asia committee adopts Paro
By: PTI-08/09/2022
Pollution exposure in infancy alters gut
By: PTI-07/09/2022
'Raktdaan Amrit Mahotsav': Registrations
By: PTI-07/09/2022
High cholesterol and weight, reduced phy
By: PTI-07/09/2022
244 dengue cases recorded in Delhi this
By: PTI-07/09/2022
Kolkata Metro to soon offer medical diag
By: PTI-06/09/2022
Can't expect Centre, state govts to give
By: PTI-06/09/2022
Active Covid cases in India decline to 5
By: PTI-05/09/2022
Padma awardee doctors suggest ways to tu
By: PTI-05/09/2022
Non-lab screening tool to assess cardiov
By: PTI-05/09/2022
UK approves second bivalent booster for
By: PTI-05/09/2022
High folic acid supplementation linked w
By: PTI-03/09/2022
Over 99% of India's population breathes
By: PTI-03/09/2022
Health ministers of WHO South-East Asia
By: PTI-03/09/2022
Aurobindo Pharma's arm to invest around
By: PTI-02/09/2022
SII will try to launch Omicron-specific
By: PTI-02/09/2022
Compound in sponges may boost immune res
By: PTI-02/09/2022
Cancer vax to cost between 200-400
By: PTI-02/09/2022
US government plans to move COVID vaccin
By: Reuters-01/09/2022
COVID-19 drives down US life expectancy
By: Reuters-01/09/2022
COVID-19 vaccine: Only 12 pc of people i
By: PTI-31/08/2022
Covishield usage highest as precaution d
By: ANI-31/08/2022
Health, insurance require parallel inves
By: TNN-31/08/2022
New Omicron Subvariant BA.2.75 is Now th
By: TNN-31/08/2022
New durable coating may kill COVID virus
By: PTI-30/08/2022
Aurobindo Pharma subsidiary's plant gets
By: PTI-30/08/2022
Monkeypox: Study reveals no instance of
By: TNN-30/08/2022
Antiviral tecovirimat found safe, effect
By: PTI-30/08/2022
Indian roads claimed 1.6L lives in 2021,
By: TNN-30/08/2022
Noida twin towers: People with respirato
By: PTI-29/08/2022
Delhi logs 397 fresh COVID-19 cases, 5 d
By: PTI-29/08/2022
Uttar Pradesh: Integrated approach will
By: TNN-27/08/2022
33% drop in Covid cases in Aug, but no.
By: TNN-27/08/2022
Mumbai: National cancer grid goes digita
By: TNN-27/08/2022
North Korea says fever cases in locked-d
By: Reuters-26/08/2022
WHO: Monkeypox cases drop 21%, reversing
By: Associated Press-26/08/2022
Indian vaccine makers grab market share
By: TNN-25/08/2022
Govt asks docs to identify suspected cas
By: TNN-25/08/2022
Singapore eases COVID-19 restrictions, m
By: PTI-25/08/2022
Pfizer COVID pill showed no benefit in y
By: Associated Press-25/08/2022
Young children are at increased risk of
By: PTI-24/08/2022
Pfizer seeks OK of updated COVID-19 vacc
By: Associated Press-24/08/2022
Nation will always be indebted to health
By: PTI-23/08/2022
Rising Monkeypox cases will not lead to
By: ANI-23/08/2022
China says COVID-19 has exacerbated decl
By: Reuters-23/08/2022
Maharashtra logs 1,183 new coronavirus c
By: PTI-23/08/2022
Rajasthan govt sanctions Rs 30 cr to pre
By: PTI-23/08/2022
Delhi reports 1,109 fresh Covid-19 cases
By: PTI-22/08/2022
Gujarat records 258 new Covid-19 cases,
By: PTI-22/08/2022
Mumbai logs 840 COVID-19 cases, zero fat
By: PTI-22/08/2022
Second-hand smoke 10th biggest risk fact
By: PTI-22/08/2022
Scientists discover ‘weak spot&rsq
By: PTI-22/08/2022
Early metformin use may cut COVID-19 hos
By: PTI-20/08/2022
ICMR planning sero-survey among contacts
By: PTI-20/08/2022
Smoking, alcohol, high BMI leading cause
By: PTI-20/08/2022
Eight hospitals to set up committees to
By: PTI-19/08/2022
Covid patients at higher risk of psychia
By: PTI-19/08/2022
Sanofi trial failure ends development of
By: Reuters-18/08/2022
Excess glucose in blood linked to mucorm