Sanofi trial failure ends development of breast cancer treatment amcenestrant

By: Reuters - 18/08/2022

Sanofi trial failure ends development of breast cancer treatment amcenestrant

French healthcare company Sanofi said it would stop further work on amcenestrant, once seen to have large potential
against breast cancer, after a second trial failure dealt a major blow to its drug development prospects.

The move puts more pressure on Sanofi to bolster its drug development pipeline as it grows increasingly dependent on its multi-billion best seller, exzecma and asthma treatment Dupixent, and after it fell far behind in the race to develop COVID-19 vaccines.

A trial dubbed AMEERA-5, which was testing amcenestrant on women with newly-diagnosed advanced breast cancer, was stopped early because an independent monitoring panel found no signs of it working.

"All other studies of amcenestrant, including in early-stage breast cancer (AMEERA-6), will be discontinued," Sanofi said. The shares dropped 1.5% shortly after the market open at 0700 GMT, for the biggest loss on the French blue chip index CAC40 In March, Sanofi's shares were hit when the company announced disappointing results of a breast cancer study involving previously treated women.

The company has previously said the drug candidate's biggest commercial opportunity was as a treatment early after diagnosis. "This was a flagship drug in pipeline and important oncology asset," wrote Credit Suisse analyst Jo Walton.

Sanofi said the drug, which was used in combination with Pfizer's established Ibrance in the study, "did not meet the prespecified boundary for continuation," when compared to a group of patients in the trial on standard hormone therapy.

Amcenestrant belongs to a drug class known as selective oestrogen receptor degraders (SERD) to fight tumours that grow in response to oestrogen, which are estimated to account for up to 80% of all breastcancer cases.

The market opportunity for oral SERDs has attracted a range of drugmakers. Sanofi's rivals including Roche and AstraZeneca are working on similar pills, known as giredestrant and camizestrant, respectively.

The drugs are designed to work like AstraZeneca's established injectable breast cancer drug Faslodex, while offering a less burdensome route of administration.

Separately, the plaintiff in the first lawsuit over the heartburn drug Zantac, which has also been weighing on the French company's shares recently, on Tuesday agreed to drop his case.

Sanofi was among a range of companies selling Zantac, which U.S. regulators pulled from the market in 2020.

(This story has not been edited by VOH and is auto-generated from a syndicated feed.)

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By: PTI-07/10/2022

New app may rapidly detect Parkinson's,

By: PTI-07/10/2022

Smoking linked with increased risk of vi

By: PTI-07/10/2022

Compound in some mouthwashes may suppres

By: PTI-07/10/2022

Dr Vivek Murthy is US representative on

By: PTI-06/10/2022

Apollo Hospitals acquires 60 pc stake in

By: PTI-06/10/2022

PM Modi inaugurates AIIMS Bilaspur

By: PTI-06/10/2022

BA.2 variant in around 90 pc Covid sampl

By: PTI-06/10/2022

Coronavirus formation modelled for first

By: PTI-06/10/2022

LIC increases its stake in Dr Reddy's La

By: PTI-04/10/2022

Singapore plans to hire 180 junior docto

By: PTI-04/10/2022

How COVID damages heart found, may lead

By: PTI-04/10/2022

Increasing number of private wards at AI

By: PTI-04/10/2022

Viral infections including COVID are amo

By: PTI-04/10/2022

From civil hospital to public health lab

By: PTI-03/10/2022

Doctors participate in walkathon to prot

By: PTI-03/10/2022

QR codes posted in Bengaluru traffic jun

By: PTI-03/10/2022

Govt to soon launch national tele-mental

By: PTI-03/10/2022

Overlapping symptoms of dengue, Covid-19

By: PTI-03/10/2022

Healthy Heart Challenge: Ensuring cardia

By: PTI-01/10/2022

New drug may turn Covid virus against it

By: PTI-01/10/2022

Delhi records three more monkeypox cases

By: PTI-01/10/2022

Lupin launches generic hypertension drug

By: PTI-30/09/2022

DCGI allows Serum Institute to export ma

By: PTI-30/09/2022

Air pollution may increase COVID severit

By: PTI-30/09/2022

Unite efforts to reduce premature mortal

By: PTI-30/09/2022

HC quashes NPPA demand notices to Bharat

By: PTI-30/09/2022

Tobacco major risk factor for heart dise

By: PTI-29/09/2022

COVID shots linked with temporary increa

By: PTI-29/09/2022

Delhi CM launches blood donation drive,

By: PTI-29/09/2022

Aesthetic surgeries to be done by regist

By: PTI-28/09/2022

Natl Clean Air Programme: Centre aims at

By: PTI-28/09/2022

SII's Adar Poonawalla makes clarion call

By: PTI-28/09/2022

Dengue cases on rise in West Bengal, 840

By: PTI-28/09/2022

New Covid-like virus found in bats could

By: PTI-27/09/2022

India's healthcare system has shown grea

By: PTI-27/09/2022

J-K has registered remarkable improvemen

By: PTI-27/09/2022

Covid helpline received 6.62 lakh calls

By: PTI-26/09/2022

PLI schemes should also focus on entitie

By: PTI-26/09/2022

New AIIMS director M Srinivas issues ord

By: PTI-26/09/2022

COVID pandemic created immunisation gaps

By: PTI-26/09/2022

New cutting-edge tech diagnoses heart fa

By: PTI-26/09/2022

COVID-19 infection increases risk of lon

By: PTI-24/09/2022

Nearly 90 pc Covid samples genome-sequen

By: PTI-24/09/2022

HC directs Delhi govt to ensure advanced

By: PTI-24/09/2022

Only 19% aged above-18 have taken 3rd CO

By: PTI-24/09/2022

Scientists engineer mosquitoes that can'

By: PTI-24/09/2022

Odisha seeks Bihar's help to check fake

By: PTI-23/09/2022

Robotic kidney transplant done at Safdar

By: PTI-23/09/2022

ICMR, IISc ink pact to create high-quali

By: PTI-23/09/2022

Assam to use portable device 'SAANS' to

By: PTI-23/09/2022

New cases of severe long COVID appear to

By: PTI-22/09/2022

Air pollution may increase hospitalisati

By: PTI-22/09/2022

Government forms committee to regulate m

By: PTI-22/09/2022

Covid-19 infection increases risk of blo

By: PTI-22/09/2022

BridgeBio Pharma, Sentynl Therapeutics g

By: PTI-22/09/2022

Discontinuation of small pox vaccine mig

By: PTI-21/09/2022

'Night owls' may have higher risk of dia

By: PTI-21/09/2022

Mizoram Governor urges people to spread

By: PTI-21/09/2022

Bihar cabinet nod for around 8,000 more

By: PTI-21/09/2022

Alzheimer's might not be primarily a bra

By: PTI-21/09/2022

11 upcoming hospitals to boost health in

By: PTI-20/09/2022

IIIT-Delhi researchers develop AI-based

By: PTI-20/09/2022

Novel test can identify patients at risk

By: PTI-20/09/2022

Indoco Remedies' CRO clears USFDA inspec

By: PTI-20/09/2022

Gujarat govt extends OPD timings in stat

By: PTI-19/09/2022

Post-ICU rehabilitation project launched

By: PTI-19/09/2022

Tata Memorial Centre inks MoU with Balco

By: PTI-19/09/2022

Indian scientist and industrialist Swati

By: PTI-19/09/2022

Portal launched recently provides info o

By: PTI-19/09/2022

Not just big pharma: how social factors

By: PTI-17/09/2022

Govt launches diabetes drug Sitagliptin,

By: PTI-17/09/2022

Active Covid-19 cases in country rise to

By: PTI-17/09/2022

WHO strongly advises against use of two

By: PTI-17/09/2022

Lancet report highlights 'massive global

By: PTI-16/09/2022

Israelis to be administered variant tail

By: PTI-16/09/2022

Malaria vaccine: the road has been long

By: PTI-16/09/2022

Single dose of alcohol may be enough to

By: PTI-16/09/2022

Another new COVID variant is spreading -

By: PTI-15/09/2022

Lancet report on unapproved antibiotic u

By: PTI-15/09/2022

Novel plastic film can kill Covid virus

By: PTI-15/09/2022

Lumpy Skin Disease: Safe to consume milk

By: PTI-15/09/2022

Make organ donation mandatory after deat

By: PTI-14/09/2022

Easy to use, more effective and cheap, n

By: PTI-14/09/2022

Twice-daily nasal saline flushing may re

By: PTI-14/09/2022

Kerala govt initiates steps to identify

By: PTI-14/09/2022

If there was SDG on COVID-19 management,

By: PTI-14/09/2022

New intranasal anti-viral treatment may

By: PTI-13/09/2022

Centre along with states trying to contr

By: PTI-13/09/2022

Paras Healthcare ties up with Fujifilm f

By: PTI-13/09/2022

Survey reveals low awareness about cance

By: PTI-12/09/2022

Lumpy skin disease: Delhi govt to procur

By: PTI-12/09/2022

WHO releases global guidelines to boost

By: PTI-12/09/2022

Drug regulator's nod sought for phase-3

By: PTI-12/09/2022

Monkeypox may cause neurological damage,

By: PTI-12/09/2022

Monkeypox vaccine expected to induce str

By: PTI-10/09/2022

WHO Regional Committee meet concludes, m

By: PTI-10/09/2022

Lupin receives US FDA approval for gener

By: PTI-10/09/2022

Zydus acquires rights to market MonoFerr

By: PTI-10/09/2022

PM Modi lauds physiotherapists, says the

By: PTI-09/09/2022

USFDA asks Panacea Biotec to take correc

By: PTI-09/09/2022

CIPACA ties up with ImpactGuru.com to of

By: PTI-09/09/2022

Two antibodies identified in Israel may

By: PTI-09/09/2022

Odisha signs MOU with Tata Memorial Cent

By: PTI-09/09/2022

US Prez Joe Biden announces launch of an

By: PTI-08/09/2022

Over 47 per cent antibiotic formulations

By: PTI-08/09/2022

Cipla gets USFDA nod for cancer drug

By: PTI-08/09/2022

WHO Southeast Asia committee adopts Paro

By: PTI-08/09/2022

Pollution exposure in infancy alters gut

By: PTI-07/09/2022

'Raktdaan Amrit Mahotsav': Registrations

By: PTI-07/09/2022

High cholesterol and weight, reduced phy

By: PTI-07/09/2022

244 dengue cases recorded in Delhi this

By: PTI-07/09/2022

Kolkata Metro to soon offer medical diag

By: PTI-06/09/2022

Can't expect Centre, state govts to give

By: PTI-06/09/2022

Active Covid cases in India decline to 5

By: PTI-05/09/2022

Padma awardee doctors suggest ways to tu

By: PTI-05/09/2022

Non-lab screening tool to assess cardiov

By: PTI-05/09/2022

UK approves second bivalent booster for

By: PTI-05/09/2022

High folic acid supplementation linked w

By: PTI-03/09/2022

Over 99% of India's population breathes

By: PTI-03/09/2022

Health ministers of WHO South-East Asia

By: PTI-03/09/2022

Aurobindo Pharma's arm to invest around

By: PTI-02/09/2022

SII will try to launch Omicron-specific

By: PTI-02/09/2022

Compound in sponges may boost immune res

By: PTI-02/09/2022

Cancer vax to cost between 200-400

By: PTI-02/09/2022

US government plans to move COVID vaccin

By: Reuters-01/09/2022

COVID-19 drives down US life expectancy

By: Reuters-01/09/2022

COVID-19 vaccine: Only 12 pc of people i

By: PTI-31/08/2022

Covishield usage highest as precaution d

By: ANI-31/08/2022

Health, insurance require parallel inves

By: TNN-31/08/2022

New Omicron Subvariant BA.2.75 is Now th

By: TNN-31/08/2022

New durable coating may kill COVID virus

By: PTI-30/08/2022

Aurobindo Pharma subsidiary's plant gets

By: PTI-30/08/2022

Monkeypox: Study reveals no instance of

By: TNN-30/08/2022

Antiviral tecovirimat found safe, effect

By: PTI-30/08/2022

Indian roads claimed 1.6L lives in 2021,

By: TNN-30/08/2022

Noida twin towers: People with respirato

By: PTI-29/08/2022

Delhi logs 397 fresh COVID-19 cases, 5 d

By: PTI-29/08/2022

Uttar Pradesh: Integrated approach will

By: TNN-27/08/2022

33% drop in Covid cases in Aug, but no.

By: TNN-27/08/2022

Mumbai: National cancer grid goes digita

By: TNN-27/08/2022

North Korea says fever cases in locked-d

By: Reuters-26/08/2022

WHO: Monkeypox cases drop 21%, reversing

By: Associated Press-26/08/2022

Indian vaccine makers grab market share

By: TNN-25/08/2022

Govt asks docs to identify suspected cas

By: TNN-25/08/2022

Singapore eases COVID-19 restrictions, m

By: PTI-25/08/2022

Pfizer COVID pill showed no benefit in y

By: Associated Press-25/08/2022

Young children are at increased risk of

By: PTI-24/08/2022

Pfizer seeks OK of updated COVID-19 vacc

By: Associated Press-24/08/2022

Nation will always be indebted to health

By: PTI-23/08/2022

Rising Monkeypox cases will not lead to

By: ANI-23/08/2022

China says COVID-19 has exacerbated decl

By: Reuters-23/08/2022

Maharashtra logs 1,183 new coronavirus c

By: PTI-23/08/2022

Rajasthan govt sanctions Rs 30 cr to pre

By: PTI-23/08/2022

Delhi reports 1,109 fresh Covid-19 cases

By: PTI-22/08/2022

Gujarat records 258 new Covid-19 cases,

By: PTI-22/08/2022

Mumbai logs 840 COVID-19 cases, zero fat

By: PTI-22/08/2022

Second-hand smoke 10th biggest risk fact

By: PTI-22/08/2022

Scientists discover ‘weak spot&rsq

By: PTI-22/08/2022

Early metformin use may cut COVID-19 hos

By: PTI-20/08/2022

ICMR planning sero-survey among contacts

By: PTI-20/08/2022

Smoking, alcohol, high BMI leading cause

By: PTI-20/08/2022

Eight hospitals to set up committees to

By: PTI-19/08/2022

Covid patients at higher risk of psychia

By: PTI-19/08/2022

Sanofi trial failure ends development of

By: Reuters-18/08/2022

Excess glucose in blood linked to mucorm