A drug already approved in the US for eye disease may stop the reproduction of SARS-CoV-2, the virus that causes COVID-19, according to a study. The results indicate that the drug called verteporfin, used for treating eye-disease, may be a candidate to treat COVID-19, and its status as FDA-approved could make it easier to launch clinical trials to verify its safety and effectiveness against the coronavirus.
The interdisciplinary study, led by University of California, Los Angeles and published in PLOS Biology, showed that the Hippo signalling pathway is activated within days of SARS-CoV-2 infection, suggesting that treatments using the mechanism could be deployed before symptoms arise to reduce the severity of disease, the study said.
Signalling pathways are complicated chain reactions which control many important human biological processes and in which certain proteins act as messenger molecules that promote or block the signals of other proteins.
The scientists, therefore, identified the Hippo signalling pathway as a potential target for therapies against the coronavirus.
The scientists performed experiments using tissue samples from people with COVID-19, as well as cultured human heart and lung cells selected to closely reflect how healthy cells respond to SARS-CoV-2 infection, the study said.
They observed changes in many genes involved with the Hippo signalling pathway after infection. In addition, they examined a protein called YAP, or Yes-associated protein, whose activity is blocked when the Hippo pathway is activated, according to the study.
The scientists found that in the cultured human cells, both the original strain and Delta variant of SARS-CoV-2 activated the Hippo pathway in the first few days after infection.
When they silenced this pathway and increased YAP, the virus replicated itself more. The team also pretreated cells with verteporfin, which blocks YAP in the eye disease known as choroidal neovascularization, and then infected them with SARS-CoV-2, the study said.
In the verteporfin-treated cells, concentrations of the coronavirus were below detectable levels, compared to more than 60,000 units of the virus per millilitre in an untreated control group, according to the study.
The lead researchers were investigating the Hippo pathway, which controls the size of organs in the body, in earlier National Institutes of Health-funded studies of the Zika virus, which can cause undersized brains in infants. Noticing that this pathway also seemed to have virus-fighting effects, they launched the current study investigating SARS-CoV-2, the study said.
(This story has not been edited by VOH and is auto-generated from a syndicated feed.)
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By: PTI-19/05/2023
Countries need to promote integration of
By: PTI-18/05/2023
Preventive healthcare in India gets shot
By: PTI-18/05/2023
Too much ultra-processed food linked wit
By: PTI-18/05/2023
WHO advises against use of sugar substit
By: PTI-17/05/2023
Naturally existing genetic resilience fo
By: PTI-17/05/2023
India likely to achieve SDG goals for re
By: PTI-17/05/2023
Private and public sectors should consid
By: PTI-16/05/2023
Prescribe generic medicines or face acti
By: PTI-16/05/2023
Himachal govt to prepare drug de-addicti
By: PTI-16/05/2023
Aakash Healthcare lines up Rs 100 crore
By: PTI-15/05/2023
AIIMS conducts successful metal-free spi
By: PTI-15/05/2023
Apollo Hospitals rolls out programme to
By: PTI-15/05/2023
Irdai sets up expert panel for matters r
By: PTI-13/05/2023
Thiruvananthapuram to host Global Ayurve
By: PTI-13/05/2023
India urges SCO member states to recogni
By: PTI-13/05/2023
Reducing regulatory intervention in syst
By: PTI-12/05/2023
ICMR, AYUSH ministry sign MoU for collab
By: PTI-12/05/2023
Sleep apnea linked to deteriorating brai
By: PTI-12/05/2023
New breathalyser test can 'sniff out' CO
By: PTI-11/05/2023
MicroRNAs in blood can tell a story abou
By: PTI-11/05/2023
Scientists use AI to develop better, sim
By: PTI-11/05/2023
Removing Darwinian evolution from textbo
By: PTI-10/05/2023
Collaborate for optimum use of resources
By: PTI-10/05/2023
2 nurses from India shortlisted for Glob
By: PTI-10/05/2023
New Delhi Municipal Council raises healt
By: PTI-10/05/2023
New 'smart' surgical implant coatings pr
By: PTI-09/05/2023
Long COVID linked with self-perceived co
By: PTI-09/05/2023
Assam govt has taken steps for cadaveric
By: PTI-09/05/2023
India ready to lead technology-driven di
By: PTI-08/05/2023
Reconstructing ancient bacterial genomes
By: PTI-08/05/2023
Sons of women with PCOS 3 times more lik
By: PTI-08/05/2023
Obesity in children is rising dramatical
By: PTI-06/05/2023
Study provides insights into heart infla
By: PTI-06/05/2023
Lupin to acquire French firm Medisol for
By: PTI-06/05/2023
India for finding permanent solution to
By: PTI-05/05/2023
Novel diagnostic test developed for chyt
By: PTI-05/05/2023
Treatment of children suffering from rar
By: PTI-05/05/2023
Strides, Orbicular to jointly develop, c
By: PTI-04/05/2023
India will get its own index to quantify
By: PTI-04/05/2023
New finding may improve type-2 diabetes
By: PTI-04/05/2023
AIIMS Delhi to create dashboards for acc
By: PTI-03/05/2023
Occludin protein in humans found to help
By: PTI-03/05/2023
DST report favours support to innovation
By: PTI-03/05/2023
Air pollution exposure linked with highe
By: PTI-02/05/2023
IIT Mandi startup develops AI-based solu
By: PTI-02/05/2023
International collaboration needed to fi
By: PTI-02/05/2023
India urges G20 countries to collaborate
By: PTI-01/05/2023
UP medical device park: 59 firms get lan
By: PTI-01/05/2023
India's vaccine market to reach Rs 252 b
By: PTI-01/05/2023
Comparative genomics helps researchers u
By: PTI-29/04/2023
Fabry disease: Advocacy group seeks Heal
By: PTI-29/04/2023
Humidity can complicate heat stress burd
By: PTI-29/04/2023
LG directs chief secretary to make 'e-pl
By: PTI-28/04/2023
Medical devices policy will make India h
By: PTI-28/04/2023
Centre to give 42 days special casual le
By: PTI-28/04/2023
Bournvita sugar content row: NCPCR asks
By: PTI-27/04/2023
PM hails Cabinet decisions approving med
By: PTI-27/04/2023
Nagaland records fewer malaria cases &am
By: PTI-27/04/2023
Need to create awareness about lead pois
By: PTI-26/04/2023
Air pollution in India linked to cogniti
By: PTI-26/04/2023
Sun Pharma launches medication to treat
By: PTI-26/04/2023
Delhi govt to provide Anganwadi centres
By: PTI-25/04/2023
Kerala will be transformed into a global
By: PTI-25/04/2023
Hawkers must be prohibited from selling
By: PTI-25/04/2023
Study sheds light on role of glucose in
By: PTI-24/04/2023
Maharashtra health minister says XBB.1.1
By: PTI-24/04/2023
COVID strain mild, SII has produced five
By: PTI-24/04/2023
FSSAI says it keeps acting against food
By: PTI-22/04/2023
Rajnath calls on medical fraternity to f
By: PTI-22/04/2023
Cause of grey hair may be 'stuck' stem c
By: PTI-22/04/2023
Narayana Health's tech choices aimed at
By: PTI-21/04/2023
Almost 90 per cent of Indians more vulne
By: PTI-21/04/2023
Alcohol abuse major cause of increase in
By: PTI-21/04/2023
Air pollution: Delhi govt to share sourc
By: PTI-20/04/2023
G20 meet: India's focus on digital healt
By: PTI-20/04/2023
Pediatric TB found to affect lung functi
By: PTI-20/04/2023
G20 delegates visit Jan Aushadhi Kendra,
By: PTI-19/04/2023
Poor diet linked to 14 million cases of
By: PTI-19/04/2023
Exhibition at G20 Health Working Group m
By: PTI-19/04/2023
Experts call for action for promoting me
By: PTI-18/04/2023
New gene discovery could lead to effecti
By: PTI-18/04/2023
India's mobile clinic initiative has les
By: PTI-18/04/2023
AIIMS holds awareness programme on Parki
By: PTI-17/04/2023
G20 HWG meet in Goa to use advocacy powe
By: PTI-17/04/2023
Manipal Health Enterprises plans to add
By: PTI-17/04/2023
Launch of new facilities will strengthen
By: PTI-15/04/2023
Disrupted sleep rhythms linked to worse
By: PTI-15/04/2023
Pfizer bivalent vaccine reduces COVID-re
By: PTI-15/04/2023
New technique may aid early Parkinson's
By: PTI-14/04/2023
Oxford University, Serum Institute of In
By: PTI-14/04/2023
Creating and implanting synthetic monkey
By: PTI-14/04/2023
COVID entering endemic stage in India, c
By: PTI-13/04/2023
Sugar molecule in blood can predict Alzh
By: PTI-13/04/2023
Health Minister Mandaviya to meet repres
By: PTI-13/04/2023
Administering mifepristone early in ecto
By: PTI-12/04/2023
Premier research bodies to conduct trial
By: PTI-12/04/2023
Model created using AI and tweets to hel
By: PTI-12/04/2023
Smriti Irani asks Meta to sync with chil
By: PTI-11/04/2023
Cipla inks licensing pact with Novartis
By: PTI-11/04/2023
COVID patients' blood shows who is most
By: PTI-11/04/2023
Nationwide COVID mock drill underway to
By: PTI-10/04/2023
J&K gets first chapter of IAPC i
By: PTI-10/04/2023
Gurugram administration issues showcause
By: PTI-10/04/2023
Deep learning model estimating breast de
By: PTI-08/04/2023
Human antibodies targeting the same vira
By: PTI-08/04/2023
Non-drug interventions to treat Alzheime
By: PTI-08/04/2023
Air pollution linked to lower COVID vacc
By: PTI-07/04/2023
Local health board in UK plans to hire h
By: PTI-07/04/2023
MP: NHM inks MoU with Heartfulness Insti
By: PTI-07/04/2023
WHO calls for urgent efforts to bridge g
By: PTI-06/04/2023
Link between obstructive sleep apnea and
By: PTI-06/04/2023
COVID infection accelerates dementia pro
By: PTI-06/04/2023
Strong link found between lithium in dri
By: PTI-05/04/2023
Spike protein of SARS-CoV-2 implicated i
By: PTI-05/04/2023
Infertility affects one in six people gl
By: PTI-05/04/2023
Right to Health Bill: Talks between stri
By: PTI-04/04/2023
Cost of 651 essential medicines down 7 p
By: PTI-04/04/2023
Cancer vaccines are being developed usin
By: PTI-04/04/2023
AIIMS mulls roping in govt agency, PSU f
By: PTI-03/04/2023
Engineered kidney could allow for early
By: PTI-03/04/2023
States responsible for implementing sche
By: PTI-03/04/2023
Odisha govt to offer free molecular test
By: PTI-01/04/2023
Model developed to fast-track effectiven
By: PTI-01/04/2023
Pharmacies to be set up at 270 stations
By: PTI-01/04/2023
USFDA issues Form-483 with 10 observatio
By: PTI-31/03/2023
Protein target found to repair heart inj
By: PTI-31/03/2023
Evidence of viral resistance to COVID-19
By: PTI-31/03/2023
Over 14 lakh severely malnourished child
By: PTI-30/03/2023
Molecule neutralising SARS-CoV-2 virus f
By: PTI-30/03/2023
ICMR's study underway to assess connecti
By: PTI-30/03/2023
HIV genomes hide behind certain WBCs, co
By: PTI-29/03/2023
Delhi HC grants time to Centre to file r
By: PTI-29/03/2023
610 cases of Covid's new variant XBB1.16
By: PTI-29/03/2023
Faceblindness is real, but many doctors
By: PTI-28/03/2023
India's heat action plans fail to identi
By: PTI-28/03/2023
Increased maternal education in India li
By: PTI-28/03/2023
Right to Health Bill: At meet with Rajas
By: PTI-28/03/2023
Metabolites regulating eye colour could
By: PTI-27/03/2023
Health as critical agenda as trade, tran
By: PTI-27/03/2023
Tube Investments, Premji Invest partner
By: PTI-27/03/2023
World TB Day: Noida has over 6,600 activ
By: PTI-25/03/2023
50% of respiratory infection cases admit
By: PTI-25/03/2023
India to pitch for open access to resear
By: PTI-25/03/2023
Women with mental illness more than twic
By: PTI-24/03/2023
Natural immune system process could trea
By: PTI-24/03/2023
President Murmu asks all stakeholders to
By: PTI-24/03/2023
Delhi Budget: Health sector gets Rs 9,74
By: PTI-23/03/2023
Inspired by no-smoking advt starring Aks
By: PTI-23/03/2023
Barriers to ADHD diagnosis and treatment
By: PTI-23/03/2023
Indigenously developed quadrivalent HPV
By: PTI-22/03/2023
Stress, anger & worry more common in the
By: PTI-22/03/2023
Long COVID infection linked with risk of
By: PTI-22/03/2023
Par panel bats for increasing budget for
By: PTI-21/03/2023
SC emphasizes on integration of Centre's
By: PTI-21/03/2023
Underactive immune response may explain
By: PTI-21/03/2023
Vaidyaratnam Group plans to double reven
By: PTI-20/03/2023
Health ministry mulls introducing centra
By: PTI-20/03/2023
Delhi HC asks IRDAI to seek policies fro
By: PTI-20/03/2023
DCGI says medicines should be sold only
By: PTI-18/03/2023