Eye-disease drug may help fight Covid

By: PTI - 10/11/2022

Eye-disease drug may help fight Covid

A drug already approved in the US for eye disease may stop the reproduction of SARS-CoV-2, the virus that causes COVID-19, according to a study. The results indicate that the drug called verteporfin, used for treating eye-disease, may be a candidate to treat COVID-19, and its status as FDA-approved could make it easier to launch clinical trials to verify its safety and effectiveness against the coronavirus.

The interdisciplinary study, led by University of California, Los Angeles and published in PLOS Biology, showed that the Hippo signalling pathway is activated within days of SARS-CoV-2 infection, suggesting that treatments using the mechanism could be deployed before symptoms arise to reduce the severity of disease, the study said.

Signalling pathways are complicated chain reactions which control many important human biological processes and in which certain proteins act as messenger molecules that promote or block the signals of other proteins.

The scientists, therefore, identified the Hippo signalling pathway as a potential target for therapies against the coronavirus.

The scientists performed experiments using tissue samples from people with COVID-19, as well as cultured human heart and lung cells selected to closely reflect how healthy cells respond to SARS-CoV-2 infection, the study said.

They observed changes in many genes involved with the Hippo signalling pathway after infection. In addition, they examined a protein called YAP, or Yes-associated protein, whose activity is blocked when the Hippo pathway is activated, according to the study.

The scientists found that in the cultured human cells, both the original strain and Delta variant of SARS-CoV-2 activated the Hippo pathway in the first few days after infection.

When they silenced this pathway and increased YAP, the virus replicated itself more. The team also pretreated cells with verteporfin, which blocks YAP in the eye disease known as choroidal neovascularization, and then infected them with SARS-CoV-2, the study said.

In the verteporfin-treated cells, concentrations of the coronavirus were below detectable levels, compared to more than 60,000 units of the virus per millilitre in an untreated control group, according to the study.

The lead researchers were investigating the Hippo pathway, which controls the size of organs in the body, in earlier National Institutes of Health-funded studies of the Zika virus, which can cause undersized brains in infants. Noticing that this pathway also seemed to have virus-fighting effects, they launched the current study investigating SARS-CoV-2, the study said.

(This story has not been edited by VOH and is auto-generated from a syndicated feed.)

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NHRC notice to Pb govt over doctors, sta

By: PTI-20/05/2023

Delhi HC constitutes committee to implem

By: PTI-19/05/2023

Global stroke deaths could increase to n

By: PTI-19/05/2023

UK university team creates Hindi video t

By: PTI-19/05/2023

Countries need to promote integration of

By: PTI-18/05/2023

Preventive healthcare in India gets shot

By: PTI-18/05/2023

Too much ultra-processed food linked wit

By: PTI-18/05/2023

WHO advises against use of sugar substit

By: PTI-17/05/2023

Naturally existing genetic resilience fo

By: PTI-17/05/2023

India likely to achieve SDG goals for re

By: PTI-17/05/2023

Private and public sectors should consid

By: PTI-16/05/2023

Prescribe generic medicines or face acti

By: PTI-16/05/2023

Himachal govt to prepare drug de-addicti

By: PTI-16/05/2023

Aakash Healthcare lines up Rs 100 crore

By: PTI-15/05/2023

AIIMS conducts successful metal-free spi

By: PTI-15/05/2023

Apollo Hospitals rolls out programme to

By: PTI-15/05/2023

Irdai sets up expert panel for matters r

By: PTI-13/05/2023

Thiruvananthapuram to host Global Ayurve

By: PTI-13/05/2023

India urges SCO member states to recogni

By: PTI-13/05/2023

Reducing regulatory intervention in syst

By: PTI-12/05/2023

ICMR, AYUSH ministry sign MoU for collab

By: PTI-12/05/2023

Sleep apnea linked to deteriorating brai

By: PTI-12/05/2023

New breathalyser test can 'sniff out' CO

By: PTI-11/05/2023

MicroRNAs in blood can tell a story abou

By: PTI-11/05/2023

Scientists use AI to develop better, sim

By: PTI-11/05/2023

Removing Darwinian evolution from textbo

By: PTI-10/05/2023

Collaborate for optimum use of resources

By: PTI-10/05/2023

2 nurses from India shortlisted for Glob

By: PTI-10/05/2023

New Delhi Municipal Council raises healt

By: PTI-10/05/2023

New 'smart' surgical implant coatings pr

By: PTI-09/05/2023

Long COVID linked with self-perceived co

By: PTI-09/05/2023

Assam govt has taken steps for cadaveric

By: PTI-09/05/2023

India ready to lead technology-driven di

By: PTI-08/05/2023

Reconstructing ancient bacterial genomes

By: PTI-08/05/2023

Sons of women with PCOS 3 times more lik

By: PTI-08/05/2023

Obesity in children is rising dramatical

By: PTI-06/05/2023

Study provides insights into heart infla

By: PTI-06/05/2023

Lupin to acquire French firm Medisol for

By: PTI-06/05/2023

India for finding permanent solution to

By: PTI-05/05/2023

Novel diagnostic test developed for chyt

By: PTI-05/05/2023

Treatment of children suffering from rar

By: PTI-05/05/2023

Strides, Orbicular to jointly develop, c

By: PTI-04/05/2023

India will get its own index to quantify

By: PTI-04/05/2023

New finding may improve type-2 diabetes

By: PTI-04/05/2023

AIIMS Delhi to create dashboards for acc

By: PTI-03/05/2023

Occludin protein in humans found to help

By: PTI-03/05/2023

DST report favours support to innovation

By: PTI-03/05/2023

Air pollution exposure linked with highe

By: PTI-02/05/2023

IIT Mandi startup develops AI-based solu

By: PTI-02/05/2023

International collaboration needed to fi

By: PTI-02/05/2023

India urges G20 countries to collaborate

By: PTI-01/05/2023

UP medical device park: 59 firms get lan

By: PTI-01/05/2023

India's vaccine market to reach Rs 252 b

By: PTI-01/05/2023

Comparative genomics helps researchers u

By: PTI-29/04/2023

Fabry disease: Advocacy group seeks Heal

By: PTI-29/04/2023

Humidity can complicate heat stress burd

By: PTI-29/04/2023

LG directs chief secretary to make 'e-pl

By: PTI-28/04/2023

Medical devices policy will make India h

By: PTI-28/04/2023

Centre to give 42 days special casual le

By: PTI-28/04/2023

Bournvita sugar content row: NCPCR asks

By: PTI-27/04/2023

PM hails Cabinet decisions approving med

By: PTI-27/04/2023

Nagaland records fewer malaria cases &am

By: PTI-27/04/2023

Need to create awareness about lead pois

By: PTI-26/04/2023

Air pollution in India linked to cogniti

By: PTI-26/04/2023

Sun Pharma launches medication to treat

By: PTI-26/04/2023

Delhi govt to provide Anganwadi centres

By: PTI-25/04/2023

Kerala will be transformed into a global

By: PTI-25/04/2023

Hawkers must be prohibited from selling

By: PTI-25/04/2023

Study sheds light on role of glucose in

By: PTI-24/04/2023

Maharashtra health minister says XBB.1.1

By: PTI-24/04/2023

COVID strain mild, SII has produced five

By: PTI-24/04/2023

FSSAI says it keeps acting against food

By: PTI-22/04/2023

Rajnath calls on medical fraternity to f

By: PTI-22/04/2023

Cause of grey hair may be 'stuck' stem c

By: PTI-22/04/2023

Narayana Health's tech choices aimed at

By: PTI-21/04/2023

Almost 90 per cent of Indians more vulne

By: PTI-21/04/2023

Alcohol abuse major cause of increase in

By: PTI-21/04/2023

Air pollution: Delhi govt to share sourc

By: PTI-20/04/2023

G20 meet: India's focus on digital healt

By: PTI-20/04/2023

Pediatric TB found to affect lung functi

By: PTI-20/04/2023

G20 delegates visit Jan Aushadhi Kendra,

By: PTI-19/04/2023

Poor diet linked to 14 million cases of

By: PTI-19/04/2023

Exhibition at G20 Health Working Group m

By: PTI-19/04/2023

Experts call for action for promoting me

By: PTI-18/04/2023

New gene discovery could lead to effecti

By: PTI-18/04/2023

India's mobile clinic initiative has les

By: PTI-18/04/2023

AIIMS holds awareness programme on Parki

By: PTI-17/04/2023

G20 HWG meet in Goa to use advocacy powe

By: PTI-17/04/2023

Manipal Health Enterprises plans to add

By: PTI-17/04/2023

Launch of new facilities will strengthen

By: PTI-15/04/2023

Disrupted sleep rhythms linked to worse

By: PTI-15/04/2023

Pfizer bivalent vaccine reduces COVID-re

By: PTI-15/04/2023

New technique may aid early Parkinson's

By: PTI-14/04/2023

Oxford University, Serum Institute of In

By: PTI-14/04/2023

Creating and implanting synthetic monkey

By: PTI-14/04/2023

COVID entering endemic stage in India, c

By: PTI-13/04/2023

Sugar molecule in blood can predict Alzh

By: PTI-13/04/2023

Health Minister Mandaviya to meet repres

By: PTI-13/04/2023

Administering mifepristone early in ecto

By: PTI-12/04/2023

Premier research bodies to conduct trial

By: PTI-12/04/2023

Model created using AI and tweets to hel

By: PTI-12/04/2023

Smriti Irani asks Meta to sync with chil

By: PTI-11/04/2023

Cipla inks licensing pact with Novartis

By: PTI-11/04/2023

COVID patients' blood shows who is most

By: PTI-11/04/2023

Nationwide COVID mock drill underway to

By: PTI-10/04/2023

J&K gets first chapter of IAPC i

By: PTI-10/04/2023

Gurugram administration issues showcause

By: PTI-10/04/2023

Deep learning model estimating breast de

By: PTI-08/04/2023

Human antibodies targeting the same vira

By: PTI-08/04/2023

Non-drug interventions to treat Alzheime

By: PTI-08/04/2023

Air pollution linked to lower COVID vacc

By: PTI-07/04/2023

Local health board in UK plans to hire h

By: PTI-07/04/2023

MP: NHM inks MoU with Heartfulness Insti

By: PTI-07/04/2023

WHO calls for urgent efforts to bridge g

By: PTI-06/04/2023

Link between obstructive sleep apnea and

By: PTI-06/04/2023

COVID infection accelerates dementia pro

By: PTI-06/04/2023

Strong link found between lithium in dri

By: PTI-05/04/2023

Spike protein of SARS-CoV-2 implicated i

By: PTI-05/04/2023

Infertility affects one in six people gl

By: PTI-05/04/2023

Right to Health Bill: Talks between stri

By: PTI-04/04/2023

Cost of 651 essential medicines down 7 p

By: PTI-04/04/2023

Cancer vaccines are being developed usin

By: PTI-04/04/2023

AIIMS mulls roping in govt agency, PSU f

By: PTI-03/04/2023

Engineered kidney could allow for early

By: PTI-03/04/2023

States responsible for implementing sche

By: PTI-03/04/2023

Odisha govt to offer free molecular test

By: PTI-01/04/2023

Model developed to fast-track effectiven

By: PTI-01/04/2023

Pharmacies to be set up at 270 stations

By: PTI-01/04/2023

USFDA issues Form-483 with 10 observatio

By: PTI-31/03/2023

Protein target found to repair heart inj

By: PTI-31/03/2023

Evidence of viral resistance to COVID-19

By: PTI-31/03/2023

Over 14 lakh severely malnourished child

By: PTI-30/03/2023

Molecule neutralising SARS-CoV-2 virus f

By: PTI-30/03/2023

ICMR's study underway to assess connecti

By: PTI-30/03/2023

HIV genomes hide behind certain WBCs, co

By: PTI-29/03/2023

Delhi HC grants time to Centre to file r

By: PTI-29/03/2023

610 cases of Covid's new variant XBB1.16

By: PTI-29/03/2023

Faceblindness is real, but many doctors

By: PTI-28/03/2023

India's heat action plans fail to identi

By: PTI-28/03/2023

Increased maternal education in India li

By: PTI-28/03/2023

Right to Health Bill: At meet with Rajas

By: PTI-28/03/2023

Metabolites regulating eye colour could

By: PTI-27/03/2023

Health as critical agenda as trade, tran

By: PTI-27/03/2023

Tube Investments, Premji Invest partner

By: PTI-27/03/2023

World TB Day: Noida has over 6,600 activ

By: PTI-25/03/2023

50% of respiratory infection cases admit

By: PTI-25/03/2023

India to pitch for open access to resear

By: PTI-25/03/2023

Women with mental illness more than twic

By: PTI-24/03/2023

Natural immune system process could trea

By: PTI-24/03/2023

President Murmu asks all stakeholders to

By: PTI-24/03/2023

Delhi Budget: Health sector gets Rs 9,74

By: PTI-23/03/2023

Inspired by no-smoking advt starring Aks

By: PTI-23/03/2023

Barriers to ADHD diagnosis and treatment

By: PTI-23/03/2023

Indigenously developed quadrivalent HPV

By: PTI-22/03/2023

Stress, anger & worry more common in the

By: PTI-22/03/2023

Long COVID infection linked with risk of

By: PTI-22/03/2023

Par panel bats for increasing budget for

By: PTI-21/03/2023

SC emphasizes on integration of Centre's

By: PTI-21/03/2023

Underactive immune response may explain

By: PTI-21/03/2023

Vaidyaratnam Group plans to double reven

By: PTI-20/03/2023

Health ministry mulls introducing centra

By: PTI-20/03/2023

Delhi HC asks IRDAI to seek policies fro

By: PTI-20/03/2023

DCGI says medicines should be sold only

By: PTI-18/03/2023