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Vaccines Work For All: Celebrating World Immunization Week 2024

"Vaccines Work For All: Celebrating World Immunization Week 2024" is a special feature highlighting the essential contributions of vaccine manufacturers in the healthcare sector. As part of World Immunization Week, this initiative aims to recognize the pivotal role played by these manufacturers in advancing global immunization efforts. From pioneering research and development to widespread distribution, vaccine manufacturers are instrumental in safeguarding public health and combating infectious diseases. Through partnerships, innovation, and dedication, these companies work tirelessly to ensure that vaccines are accessible to people of all ages and backgrounds. Join us in celebrating their unwavering commitment to protecting lives and promoting a healthier world for all.


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Bharat Biotech: Leading the Charge in Global Immunization Efforts


Bharat Biotech (BBIL) is a biotech company in Genome Valley, Hyderabad, India. BBIL is a global leader with 145 patents, ~20 vaccines and bio-therapeutics, and registrations in 125 countries. These vaccines developed with clinical trials in more than 20 countries worldwide and more than 100 publications in peer-reviewed journals. The company has manufactured and supplied more than 9 billion doses of vaccines globally, saving millions of lives and livelihoods annually.


Work Done in Immunization


The company has world-class vaccine and bio-therapeutics research, product development, manufacturing, and distribution facilities. BBIL has developed vaccines for infectious diseases, including Hepatitis B, Pentavalent (DPT+HepB+Hib), Rabies, Typhoid, polio, H1N1 influenza, Japanese Encephalitis (JENVAC®), India’s first Rotavirus vaccine, the world’s first Typhoid conjugate vaccine, TYPBAR TCV®, novel vaccines for covid-19 such as COVAXIN® and INCOVACC®. BBIL introduced WHO pre-qualified vaccines namely BIOPOLIO®, ROTAVAC®, ROTAVAC 5D®, and TYPBAR TCV® in several countries worldwide. BBIL has a strong pipeline of innovative vaccines against Malaria, Cholera, Tuberculosis, Paratyphi A, Non-Typhoidal Salmonella, Chikungunya, Zika, etc. The acquisition of Chiron Behring Vaccines has positioned Bharat Biotech as one of the world's largest rabies vaccine manufacturers with CHIRORAB® and INDIRAB®.


Dr. Krishna Ella, Executive Chairman, Bharat Biotech



Vision: To offer affordable, safe, and effective healthcare solutions to combat mankind’s dreaded illnesses and to thus eradicate or at least control their occurrence in the years to come.


Mission: We seek to address the healthcare needs of the people in emerging markets by driving innovation and being a frontrunner in the research and development of new vaccines and bio-therapeutics.


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Serum Institute of India: Leading the Global Fight Against Infectious Diseases



Serum Institute of India Pvt. Ltd. (SII) is the world's largest vaccine manufacturer by number of doses produced and sold globally (more than 1.5 billion doses) which includes Polio vaccine, Diphtheria, Tetanus, Pertussis, Hib, BCG, r-Hepatitis B, Measles, Mumps, Rubella as well as Pneumococcal and Covid-19 vaccines. It is estimated that about 65% of the children in the world receive at least one vaccine manufactured by SII. Vaccines manufactured by SII are accredited by the World Health Organization, Geneva, and are being used in around 170 countries across the globe in their national immunization programs, saving millions of lives throughout the world. Serum Institute of India is ranked as India's No. 1 biotechnology company, manufacturing highly specialized life-saving biologicals like vaccines using cutting-edge genetic and cell-based technologies, antisera, and other medical specialties. Serum Institute of India was founded in 1966 by Dr. Cyrus Poonawalla to manufacture life-saving immuno-biologicals, which were in shortage in the country and imported at high prices. Thereafter, several life-saving biologicals were manufactured at prices affordable to the common man and in abundance, with the result that the country was made self-sufficient for Tetanus Anti-toxin and Anti-snake Venom serum, followed by DTP (Diphtheria, Tetanus, and Pertussis) group of Vaccines and then later on MMR (Measles, Mumps, and Rubella) group of vaccines. In the global fight against infectious diseases, vaccines stand as one of the most effective tools. Serum Institute of India (SII), the world's largest vaccine manufacturer by volume, has been at the forefront of this battle, producing a vast array of vaccines that cater to a multitude of health needs.


Work done in the immunization sector:


COVID-19 Vaccine - COVISHIELD


COVISHIELD, developed by SII in collaboration with the University of Oxford and AstraZeneca, has been a cornerstone in India's fight against the COVID-19 pandemic. Beyond India, COVISHIELD has been pivotal in global vaccination efforts, widely adopted by numerous countries through international collaborations and supply agreements. Its success lies not just in its ability to protect individuals but also in its contribution to curbing the spread of the virus, facilitating the gradual return to normalcy across the globe.With its robust safety profile, affordability, and broad accessibility, COVISHIELD continues to play a crucial role in safeguarding public health and paving the way towards ending the COVID-19 pandemic.


Bacterial Vaccines: SII offers a comprehensive range of bacterial vaccines that protect against diseases like Diphtheria, Tetanus, and Pertussis.


Viral Vaccines The institute's viral vaccines protect against diseases such as Measles, Mumps, Rubella, and Rotavirus. Combination Vaccines SII has also developed combination vaccines that protect against multiple diseases in a single shot.


HEXASIIL: Protects against Diphtheria, Tetanus, Pertussis, Hepatitis B, Poliomyelitis & Haemophilus influenzae Type b


Pentavac PFS: Guards against Diphtheria, Tetanus, Pertussis, Hepatitis B, and Haemophilus Type b


Polysaccharide Conjugate Vaccines: SII provides vaccines like the Haemophilus influenzae Type B conjugate Vaccine Influenza Vaccines NASOVAC-S: An Intranasal Influenza Vaccine for Pandemic strains NASOVAC-S4: A seasonal, quadrivalent, live attenuated intranasal influenza vaccine.


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Central Research Institute: Pioneering Immunization Solutions for Over a Century






CRI, located in Kasauli, Himachal Pradesh, is a pioneering Public Sector Unit of the Government of India, specializing in immunology since 1905. With over 120 years of history, it serves as a vital research center, manufacturing life-saving vaccines and antisera, and providing national-level surveillance for infectious diseases. CRI's contributions include supplying vaccines such as DTWP, DT, TT, AKD, Anti-Rabies, Cholera, JEV, and YFV. Presently, it manufactures and supplies DPT vaccines to UIP and various therapeutic antisera, while also offering diagnostic antigens and antisera for diseases like typhoid and cholera. Collaborating with WHO, CRI conducts surveillance for various viruses and serves as the National reference center for Salmonella typhi and Escherichia coli. Additionally, CRI fosters human resource development through training and academic courses in immunology, microbiology, and vaccinology.


Work Done in Immunizations


From 1906 to 2008, CRI manufactured and supplied rabies vaccine and rabies Serum across the country to meet the 100 % demand thereby providing indigenous treatment of rabies in India. CRI has manufactured and supplied millions of doses of all the above-listed vaccines under various Government Health Programmes. For more than four decades, 70 % of the Nation's demand for various vaccines under UIP was fulfilled by CRI. During World War II, the Institute supplied over a hundred thousand doses of vaccines and antisera per month to the defense forces posted in India, Egypt, and Mesopotamia, which was a record production in those times. During the war years i.e. from 1939 to 1946, manufacturing of vaccines and antisera reached the unprecedented tally of one million doses per month. Currently, the Institute is manufacturing a DPT group of vaccines and has supplied approximately 240 lakh doses (2023-24) of DPT vaccine to the universal immunization program. The Institute supplies the total requirement of yellow fever vaccine of the country, imported through WHO. The Institute is also in the process of production and supply of Td vaccine to UIP. To contribute significantly in National Health Programme as per Vaccine Policy, the institute has planned to expand its vaccines (Both UIP and Non-UIP) horizon to other vaccines such as Japanese Encephalitis Vaccine (JEV), Hib Conjugate, Typhoid Conjugate Vaccine, Meningococcal (Men A/C/Y/W/135) conjugate-Pentavalent, Conjugate Pneumococcal, Hepatitis-B Vaccine, Anti-rabies vaccine (TC-ARV), Human Papilloma Virus (HPV) vaccine and KFD vaccine.


CRI Director’s Message - Dr. Dimple Kasana"The Distance between your dreams and reality is called Discipline"


Central Research Institute, Kasauli has an illustrious past spanning more than a hundred years and has been serving the nation by producing and supplying life-saving Vaccines and Antisera. I began my journey as the Director of this institute in 2021 and feel proud to be associated with this institution, since it has a glorious legacy behind it, and grateful for getting an opportunity to contribute to the pioneering achievements of great scientists like Sir David Semple. As the institute is about to complete its journey of 120 years, I feel confident that CRI will achieve many more milestones in the coming years and will remain a significant body in the health sector of our country. CRI is in the continuous process of commercial production and supply of the DPT vaccine to the Universal Immunization Programme and is all set to manufacture and supply the Td vaccine. CRI has also submitted proposals for the development of cGMP-compliant facilities for various bacterial and viral vaccines to strengthen the Universal Immunization Programme. CRI is also determined to expand its sphere by introducing diverse activities related to applied research in the interest of public health. To achieve this, we are working hard to enhance and upgrade our infrastructure along with building new collaborations. Very soon, we are going to establish a BSL-3 facility at CRI Kasauli, which is going to play a pivotal role in the management of emerging contagious diseases. Working on the vision of India's skill development mission, the institute also runs multiple courses and Industrial training programs to build an educated, trained, and efficient workforce for the future. I assume that with the current technical workforce of CRI, Kasauli, and the guidance and assistance of the Directorate General of Health Services and the Ministry of Health & Family Welfare, we would be able to expand our capabilities in the world of vaccinology.


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Zydus Lifesciences Limited: Advancing Immunization for Healthier Communities



Zydus Lifesciences Limited, (formerly Cadila Healthcare Limited), holds a prominent position in India's pharmaceutical sector, with a global presence offering comprehensive healthcare solutions. Operating across the pharmaceutical value chain, from formulations to active pharmaceutical ingredients and wellness products, Zydus is renowned for its steadfast commitment to addressing unmet healthcare needs and promoting healthier communities worldwide.


Work Done In Immunization


Under its division Zydus Vaxxicare, the company is deeply dedicated to enhancing immunization rates in India, focusing on diseases such as influenza, typhoid, measles-mumps-rubella, and rabies. By upholding international standards in local vaccine manufacturing strengthening Atma Nirbhar Bharat Abhiyan. Zydus Vaxxicare aims to significantly impact vaccination efforts in the country, engaging healthcare professionals and patients through robust awareness initiatives.


Message From The Leaders Mr. Samir Desai, President -Biologics at Zydus Lifesciences Ltd.: Emphasizes the company's holistic health approach, stressing the pivotal role of vaccination in disease prevention. He highlights the importance of vaccines in combating illnesses like influenza, typhoid, and rabies, emphasizing their contribution to achieving global health objectives, such as ending rabies deaths by 2030.


Mr. Nitin Jain, Vice President of Zydus Vaxxicare and EqualsTwo divisions, echoes this perspective: Emphasizing the crucial nature of vaccination across all age groups, particularly among high-risk populations facing multiple health challenges. He mentions various scientific and awareness initiatives where Zydus collaborates with esteemed medical societies in India, to bolster awareness and medical education within healthcare communities, thus enhancing immunization rates across all age groups.


The enduring memory of COVID-19 vaccination underscores a crucial lesson


Vaccination is not solely for infants and toddlers but extends its benefits to all age groups. Recognizing the importance of vaccination across all demographics, Zydus has initiated its flagship initiative "Life Course vaccination," aiming to prevent vaccine-preventable diseases throughout an individual's lifespan.


Elevating vaccination rates is pivotal in alleviating the burden of vaccine-preventable diseases, particularly in a country like India, where it could significantly impact healthcare burdens. Zydus Lifesciences Limited reaffirms its commitment to advancing public health outcomes and fostering a healthier society for all.


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Empowering Healthier Futures: AstraZeneca's Commitment to Immunization

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines, primarily for the treatment of diseases in four therapy areas - Oncology, Cardiovascular, Renal & Metabolism, and Respiratory and Rare Diseases. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Established in 1979, it is headquartered in Bengaluru, Karnataka, and has a workforce of over 700 employees across the country committed to delivering great medicines to patients through innovative science and global excellence in development and commercialization.


Work Done in Immunization


COVID-19 emerged as a profound challenge in healthcare, prompting AstraZeneca to act swiftly in alignment with our core values-- to follow the science, put patients first, and do the right thing. Our response to the COVID-19 (novel coronavirus) outbreak exemplified our commitment to follow science, prioritize patient care, and uphold ethical standards.


AstraZeneca mobilized its COVID-19 research efforts to focus on key areas: identifying novel coronavirus-neutralizing antibodies against the SARS-CoV-2 virus to prevent or treat disease progression; and investigating the application of our new and existing medicines to suppress the body’s overactive immune response, or protect from serious complications, such as organ failure caused by COVID-19 disease. Our priorities included ensuring the continued supply of our medicines to patients, safeguarding the health and well-being of all our employees as well as communities, and mobilizing our research efforts to discover and deliver solutions against the COVID-19 disease.


Our groundbreaking vaccine development partnership with Oxford University further underlined our commitment to equitable healthcare access, exemplified by our collaboration with Serum Institute in India to ensure broad vaccine availability nationwide. Collaborating globally, including with partners like the Serum Institute of India, we supplied over 3 billion doses of our vaccine at cost, playing a crucial role in the fight against COVID-19, the most significant global health crisis in recent history. The impact was profound, with Vaxzevria estimated to have saved over 6 million lives by December 2021, as per model projections.


We are making progress across our Vaccine and Immune Therapies portfolio and our ambition to deliver long-lasting immunity and protection against infectious diseases that affect millions of people around the world. We are engineering next-generation vaccines that have the potential to generate potent and long-lasting immune responses. For those who cannot mount an immune response to vaccines, AstraZeneca has been pioneering novel approaches to develop highly targeted, long-acting antibodies optimized with our half-life extension technology, which have the potential to play an increasing role in reducing the burden of disease caused by flu, COVID-19 and respiratory syncytial virus (RSV), in addition to other diseases such as cancer and respiratory diseases.


Vision of AstraZeneca


We’re a science-led, patient-focused global pharmaceutical business committed to excellence in the research, development, and commercialization of prescription medicines that aim to transform the lives of patients with improved outcomes and a better quality of life. At AstraZeneca, our vision centers on leveraging science to create innovative therapies, improving the lives of those with chronic diseases. Our strong focus on science drives our pipeline of life-changing medicines, aiming for more effective treatment and prevention of complex diseases. We prioritize specialized disease areas, focusing on cancer, chronic, and rare diseases, where we believe we can make a significant impact. Through our Growth Through Innovation strategy, we're committed to delivering best-in-class medicines across all therapy areas. Our dedication to long-term positive impact and sustained innovation reflects our deep understanding of unmet healthcare needs in India, driving transformative solutions and redefining standards of care. We’re transforming the future of healthcare by unlocking the power of what science can do for people, society, and the planet.


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Equitable Access to Vaccines: Pfizer's Ongoing Commitment to Global Health



The importance of life course immunization approach and Need for Pneumococcal Vaccination


At Pfizer, we believe vaccination is one of the best ways possible to help protect infants, children, and adults against infectious diseases. We aspire to fundamentally transform infectious disease prevention so that people of all ages can live longer and healthier lives.


Vaccine-preventable diseases are increasingly affecting the Indian population – for instance, India is responsible for 25% of the global pneumonia burden. Fortunately, vaccines form safe, proven, and effective solutions to prevent infection – helping people seek an enhanced quality of life while extending layered protection across the community. This is vital not just in childhood, but across all stages of life, including in adulthood and well into old age, as the protective benefits of childhood vaccines weaken over time.


Pneumococcal disease, a group of illnesses caused by the bacterium Streptococcus pneumoniae (S. pneumoniae), is a leading cause of vaccine-preventable death in children worldwide, with the majority of these deaths occurring in developing countries.


Life-course immunization approach is important


Yet, we must confront a glaring reality: while infants receive due attention in vaccination efforts, the immunization rates among adults in India remain alarmingly low. This may put adults the elderly population (over 50 years of age) and those with comorbidities, including asthma, diabetes, cardiovascular diseases, and more at increased risk of infections such as pneumococcal disease. Life-course immunization is an important, helpful solution to help people lead healthier lives.


At Pfizer, we are leveraging the power of science and our expertise in research and design as we strive to pave the path for a healthier tomorrow. We are committed to helping bridge India’s gap in adult vaccination coverage by creating and championing vaccines as a solution to scale support for public health.


Over the years, Pfizer has made several breakthroughs and led meaningful partnerships and awareness initiatives to advocate for adult vaccination. Through its initiatives, the company has championed patient-centricity in care delivery, ensuring that every at-risk individual who seeks healthcare – whether during routine check-ups, corporate health assessments, outpatient visits, or inpatient care – receives comprehensive education on the critical role that immunization plays in safeguarding health. Additionally, its vaccination solution has been available in India for over a decade.


Building an ecosystem for adult vaccination through the establishment of COEs


Pfizer has also scaled access to adult vaccination across different regions in the country by forging strategic partnerships with over 150 corporate hospitals to establish more than 10 Centers of Excellence (COE), including Royal Care Hospital, Apollo Hospital, and Yashoda Hospitals. These are carefully designed, including redefining protocols and infrastructure, to prioritize preventive health and increase the adoption of adult vaccination. The COEs also empower healthcare practitioners, offering useful information to enhance their understanding of the long-lasting benefits of adult vaccination. These efforts reinforced the convictions of over 4,000+ healthcare practitioners, built the capabilities of more than 500+ nurses, and have created over 100+ vaccination protocols. This is done by sharing resources and upskilling opportunities, as well as by establishing scientific panel discussions and more.


Continuous Medical Education to drive awareness for adult immunization


Pfizer has also introduced educational programs for healthcare professionals and paramedics and has led multiple initiatives to scale access and awareness on the latest up-to-date information on vaccines. It also published a white paper on employee vaccination. Pfizer has led the top-of-mind recall for vaccination with a laser-sharp focus on creating urgency for adults aged 50+ years with its successful Duty@50 campaign and aligning vaccination with treatment goals of HCPs across specialties pulmonologists, nephrologists & CPs.


Our commitment to vaccine innovation and equitable access


Still, we know our work is not done. From changing climates that now allow certain pathogens to thrive and increased movement to urban areas, to people traveling within and across borders, the world faces several realities that all facilitate the transmission of infectious diseases. Working to ensure equitable access and accelerate the availability of potentially life-saving vaccines around the world is a key component of our commitment to improving global health. Our industry-leading pipeline, scientific expertise, and end-to-end global capabilities put Pfizer at the forefront of a new era of vaccine innovation to help address these realities. We continue to advance our leadership in vaccines against pneumococcal and meningococcal disease, deliver breakthroughs to help prevent respiratory syncytial virus (RSV) in older adults and infants from birth through age 6 months through maternal immunization, and explore the potential of vaccines to help protect against other diseases like maternal Group B streptococcus bacteria (GBS) and an mRNA-based flu vaccine. Driving our efforts are the many millions of lives around the world that are depending on us.


Disclaimer: While this feature highlights specific organizations, there are many other vaccine manufacturers playing a crucial role in global immunization efforts.

30 April 2024

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